Journal: bioRxiv
Article Title: Conserved fiber topography of the anterior limb of the internal capsule in treatment-resistant psychiatric patients
doi: 10.64898/2026.05.11.724148
Figure Lengend Snippet: A. ALIC DBS electrode placement in TRD patients. Individual ALIC contacts were stimulated to generate evoked potentials in the vPFC. B. sEEG leads in the vPFC of TRD patients. sEEG electrodes sampled the medial-lateral extent of the vPFC, with the exact placement varying by patient and hemisphere. C-D. Each DBS ALIC contact is shown in MNI space, colored according to the correlation between vPFC sEEG contact medial-lateral position and CCEP amplitude. Hotter colors indicate greater response in medial vPFC; cooler colors indicate greater responses in lateral vPFC. Overall, in the left hemisphere, ventral ALIC stimulation sites were associated with greater CCEP responses in the medial vPFC, whereas dorsal ALIC stimulation sites were associated with greater CCEP responses in the lateral vPFC, recapitulating established topographies.
Article Snippet: TRD patients underwent stereotactic implantation of four segmented DBS leads (Boston Scientific Cartesia) bilaterally in the VC/VS and SCC, and ten temporary sEEG recording electrodes (PMT Corporation, MN, USA) positioned using pre-operative patient-specific tractography-guided planning to help interpret network activity ( , ). sEEG electrodes had 12 to 16 intracranial depth contacts each with a 0.8 mm diameter and a 3.5 center-to-center distance that enable neural activity recording in cortical, subcortical, and white matter regions.
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